|Films||Elena and the Secret of Avalor|
|Shows||Elena of Avalor|
|Occupation||Princess of Avalor|
|Friends||Alacazar, Mateo, Migs, Luna and Skylar, Gabe, Naomi Turner, Cristina, Princess Caterina,Princess Sofia, King Roland II, Queen Miranda, Prince James, Princess Amber|
|Family||King Raul (father; deceased)|
Queen Lucia (mother; deceased)
Princess Elena (older sister)
Francisco (maternal grandfather)
Luisa (maternal grandmother)
Chancellor Esteban (maternal first cousin)
|Enemies||Shuriki, Orizaba, Fiero, Victor Delgado, Carla Delgado, Marimonda|
|Likes||Inventing, writing, having fun with her sister, drawing, bunuelos, learning new things, her go-pack|
|Dislikes||Her inventions going wrong, broken promises, Dia de los Muertos (formerly), her older sister taking costly risks, being judged|
41 years before the start of the special, Isabel and Elena's parents were murdered by Shuriki, allowing her to usurp the throne. In an attempt to protect her, Elena distracted Shuriki while Alacazar casted a spell to place Isabel and her grandparents in an enchanted painting for their protection. It succeeded, but Elena was imprisoned in the Amulet of Avalor, and Shuriki was able to take over Avalor with Esteban as her Chancellor.
41 years later, Alacazar's grandson, Mateo, casts the spell to free Isabel and her grandparents from the painting, allowing them to reunite with Elena, who had been freed from the Amulet by Sofia. Aided by Sofia's family of King Roland II, Queen Miranda, Prince James, Princess Amber, and the citizens of Avalor City, Elena defeats Shuriki, destroys her wand, and reclaims Avalor, assuming the throne as Crown Princess in her late parents' stead and also allowing Isabel to reclaim her position as Princess and heir to the throne as well, giving Enchancia a valuable new ally in Avalor.
Following Elena reclaiming the throne from Shuriki, Isabel spends her time creating new inventions to help out her family, the Jaquins, or the people of Avalor City, even if it causes her to get into trouble sometimes because of them. However, she is unaware that Shuriki survived, and having allied with former allies in Victor and Carla Delgado, is planning revenge against Elena and the Jaquins, with her ultimate goal being Isabel and Elena's late mother, Queen Lucia's, Carnaval Tiara as Shuriki can use the jewel in it to forge a new wand to replace the one Elena snapped in half previously to restore her powers and launch a second coup against Elena, Isabel, their family, and the Jaquins. Unaware of that at first, Isabel enrolls in a local Avalor public school, meets some new friends around her age in her classmates, and even takes part in the annual Avalor Science Fair, earning her a chance to meet her idol, Professor Ochoa, and be enrolled in the Avalor Science Academy for a class once a week with Ochoa as well. Isabel has not been told yet of Shuriki's return by Elena, Esteban, or her grandparents, but presumably has been at some point.
- This is the second character played by Jenna Ortega who is a young inventor, the first being Harley Diaz from Stuck in the Middle.